A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Johny, Mary Sruthi
- Analysis of Clinical Pharmacist Reported Adverse Drug Reactions from Oncology Department in a Tertiary Care Hospital
Authors
1 Amrita School of Pharmacy, Kochi, IN
2 Pharmacovigilance of India, AIMS, IN
3 Oncology Department, AIMS, IN
4 Department Medical Oncology & Hematology, AIMS, IN
Source
Journal of Pharmaceutical Research, Vol 14, No Special Ed (2015), Pagination: 57-57Abstract
Adverse drugs reactions (ADRs) are noxious, unintended, and undesirable effects that occur as a result of drug treatment at doses normally used in man for diagnosis, prophylaxis, and treatment.Due to the limitations of clinical trials, it is not possible to have a complete knowledge regarding all ADRs at the time of drug approval, necessitating drug safety follow-ups after releasing to the market. Pharmacovigilance has been defined as a science regarding the detection, assessment, understanding and prevention of ADRs, with its ultimate goal being improving pharmacotherapy. The most important finding of this study is the significant improvement in ADR reporting after education and establishment of Pharmacovigilance Centers.
In this study we collected and analyzed the adverse drug reactions reported by clinical pharmacist from oncology department to pharmacovigilance, 101 adverse drug reaction cases were reported from oncology to pharmacovigilance for a period of 11 months (September 2014-july 2015).
It was found that out of 101 cases, 51 males (50.49%) and 50 females (49, 50%) ADR cases were reported. Among which most reported were from between the age group 60-70 yrs (24 cases with 23.76%) with case of ALL (24 cases with 23.76%) which was treated with L-Asparginase.From the whole study done, itching (24 cases with 23.76%) was the most occurant Adverse Drug Reaction.
As a clinical pharmacist, it is our duty to encourage and educate other healthcare professionals for reporting adverse drug reactions.
We hereby conclude that clinical pharmacy service has an excellent role in designing and conducting the pharmacovigilance system in the hospitals by establishing specified centers with clearly defined objectives and tasks.
Keywords
PV (Pharmacovigilance), ADRs (Adverse Drug Reactions).- Augmentin Induced Steven Johnson Syndrome : Case Report
Authors
1 Amrita School of Pharmacy, Kochi, IN
2 Pharmacovigilance Programme of India, Amrita Institute of Medical Sciences, Kochi, IN
3 Department of Oncology, Amrita Institute of Medical Sciences, Kochi, IN
4 Amrita Institute of Medical Sciences, Kochi, IN
Source
Journal of Pharmaceutical Research, Vol 14, No Special Ed (2015), Pagination: 86-86Abstract
Steven Johnson Syndrome (SJS) is an acute systemic disorder presenting as severe mucosal erosions with erythematous , cutaneous macules or atypical targets.Here we discussed a case of 39 year old women who developed drug induced steven Johnson syndrome (SJS). she was on Amoxicillin - Clavulanic acid(penicillin antibiotic) and Paracetamol for the management of fever and cough. Later she developed peeling of skin over lips , painful reddish lesions over 75% of her skin surface including back of trunk, front of chest, hands, legs, palms and soles. Her eyes, mouth and genital organs were also affected.
Blood investigations revealed LFT was elevated herpes simplex virus IgM was borderline and IgG HSV was elevated( 5.5). her blood cultures were negative.
Patients symptoms started to develop on 2nd day of treatment with amoxicillin/clavulanic acid( Augmentin) 625mg OD. adverse reaction was managed with IV steroids,oral cyclosporine and other conservative measures. After 2 weeks her lesions subsided and steroids were tapered. During her discharge, she was haemodynamically stable, LFT was improved and her lesions were exfoliating.
Health care providers must be careful regarding the adverse effects of the drugs especially the one is the Stevens-Johnson syndrome (SJS) which is a potentially fatal condition with mortality rate below 5 percent.
This reaction is of shorter duration and with rechallenge. The most commonly and widely prescribed drug regimens should also be used judiciously and continuously monitored to prevent such a fatal adverse drug reactions.